Genome-scale sequencing projects have led to an explosion of genetic sequences available for automated analysis. These gene sequences are the codes, which direct the production of proteins that in turn regulate all life processes. The student will be shown how these sequences can lead to a much fuller understanding of many biological processes allowing pharmaceutical and biotechnology companies to determine for example new drug targets or to predict if particular drugs are applicable to all patients. Students will be introduced to the basic concepts behind Bioinformatics and Computational Biology tools. Hands-on sessions will familiarize students with the details and use of the most commonly used online tools and resources. The course will cover the use of NCBI's Entrez, BLAST, PSI-BLAST, ClustalW, Pfam, PRINTS, BLOCKS, Prosite and the PDB. An introduction to database design and the principles of programming languages will be provided.Introduction to Structural Bioinformatics
This course introduces students to the practical application of structure and sequence analysis, database searching and molecular modeling techniques to study protein sequence, structure and function. Amino acid properties and protein secondary structures will be reviewed as supporting information for understanding the importance of protein sequence. Internet resources, molecular visualization software, and computational algorithms will be introduced to the student for structure analysis. It is anticipated that the student will gain practical knowledge in using software techniques and internet resources to handle and compare sequence and structure information, search databases and interpret protein structure.
http://www.bioinformaticscourses.com/ISB/index.html Computer Skills for Biotechnology (CSUSM BIOL358)
This course is designed to introduce and explain the application of computational and analytical methods to address problems in biotechnology. Many popular software tools employed in biotechnology and bioinformatics research will be covered. The theoretical basis governing the use and importance of these tools will be explored.
http://www.bioinformaticscourses.com/BIOL358/ Bioinformatics in Target Identification and Validation
This is a 2 hour lecture given as part of the UCSD Extension Target Identification and Validation course organized by Leonard Miller, Ph.D.
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